NPS — Nonparametric Superposition | Multiple Dose Prediction

Single-Dose Profile Data

Enter single-dose concentration-time data. You may paste directly from Excel/Sheets.
Multi-subject data supported — select number of groups below.

Groups: Each group = one subject/animal. Columns: Time, Group1, Group2, ...

Smart Parse

Instant

Paste anything — CSV, Excel table, JSON, or text. Multi-subject data is auto-detected. Data will be loaded into the spreadsheet above and parsed automatically.

PK Parameters

λz (1/hr)

Reference Dose (D_ref)

Values from NCA analysis — λz is the terminal elimination rate constant

Profile Preview

Enter data and click Parse to preview

Algorithm Reference

Interpolation

Pre-Tmax: Linear | Post-Tmax descending: Log-linear

Extrapolation

Beyond T_last: mono-exponential decay with λz

Superposition

Model-free summation of dose-normalized contributions

Dosing Regimen

Set up dosing schedule. Irregular regimens are fully supported.

Quick Setup

Dose

τ (hr)

N Doses

Time (hr) / Dose

Predicted Profile

Total Per-dose

Run superposition to see prediction

Steady-State Settings

Predict steady-state PK profile under uniform dosing. Simulates until 10 × t½.

Dose Amount

τ (Dosing Interval, hr)

Override N Doses (optional)

SS Profile

Configure and run SS prediction

Engine Validation — Bguide1 Test Suite

Validates NPS engine using Bguide1 example data (Theophylline 320 mg oral, λz ≈ 0.0866 hr⁻¹).

Click "Run Tests" to execute the validation suite.